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Thursday, November 3, 2016
Highlighted Artcile: Metalloporphyrins in Drug and Pesticide Catalysis as Powerful Tools to Elucidate Biotransformation Mechanisms
Metalloporphyrins in Drug and Pesticide Catalysis as Powerful Tools to Elucidate Biotransformation Mechanisms
Author(s):
Lucas D. Zanatta, Isaltino A. Barbosa, Paulo C. de Sousa Filho, Fabricio B. Zanardi, Lucas B. Bolzon, Osvaldo A. Serra and Yassuko Iamamoto Pages 281 - 288 ( 8 )
Abstract:
Water pollution levels are rising worldwide, so new tools that can over- come the harmful effects of pollutants to the environment and living organisms are welcome. In this context, metalloporphyrins (MePs) mimicking cytochrome P-450 enzymes can contribute to the production of metabolites and help to elucidate bio- transformation processes. MePs can promote chemo-, regio-, and stereoselective transformations under mild conditions, which is highly desirable when investigating the metabolism of drugs or pesticides that currently contaminate natural waters. MeP models can be tailored by introducing electrophilic groups into different posi- tions of the porphyrin ring and by choosing suitable oxygen donors to activate the catalyst and generate the high-valence intermediate species. This mini-review aims to show a recent breakthrough in the use of MePs as a powerful tool to predict which metabolites arise during biotransformation assays. It also aims to highlight the versatility of such models regarding the current challenges in catalytic conversion of xenobiotics.
Keywords:
Biomimetic catalyst, drug, metabolism, metalloporphyrin, oxidation, pesticide.
Affiliation:
Department of Chemistry - Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto - University of Sao Paulo.Ribeirao Preto, SP, Brazil.
Graphical Abstract:
For More Information Please Visit Our Website Mini Review in Organic Chemistry
Thursday, October 27, 2016
Most Accessed Article: Review of Methods and Various Catalysts Used for Chalcone Synthesis
Review of Methods and
Various Catalysts Used for Chalcone Synthesis
Author(s):
Syed Nasir Abbas Bukhari, Malina Jasamai,
Ibrahim Jantan and Waqas Ahmad Pages 73 - 83 ( 11 )
Abstract:
Chalcones are the main precursors for the
biosynthesis of flavonoids and isoflavonoids. Chalcones comprise of a three
carbon α, β-unsaturated carbonyl system. These are the condensation products of
aromatic aldehyde with acetophenones in the presence of catalyst. They go through
a variety of chemical reactions and are found beneficial in synthesis of
pyrazoline, isoxazole and an assortment of heterocyclic compounds. Chalcones
play pivotal role in synthesizing a range of remedial compounds. They have
exhibited impressive curative efficacy for the treatment of numerous diseases.
Chalcone based derivatives have gained focus since they possess simple
structures and sundry pharmacological actions. A number of techniques and
schemes have been reported for the synthesis of these compounds. Amongst all
the stated methods, Aldol condensation and Claisen-Schmidt condensation still
hold high position. Other renowned techniques include Suzuki reaction, Witting
reaction, Friedel-Crafts acylation with cinnamoyl chloride, Photo-Fries
rearrangement of phenyl cinnamates etc. These innovative techniques employ
various catalysts and reagents including SOCl2 natural phosphate, lithium
nitrate, amino grafted zeolites, zinc oxide, water, Na2CO3, PEG400,
silicasulfuric acid, ZrCl4 and ionic liquid etc. The development of improved
strategies for the synthesis of α, β- unsaturated carbonyl compounds is still
in demand. Briefly, we have explained the methods and catalysts used in the
synthesis of chalcones in a review form to provide information for the development
of new-fangled processes aiming better yield, less reaction time and minimum
side effects.
Keywords:
Chalcones, claisen-schmidt condensation,
flavonoids, anticancer, anti- inflammatory
Affiliation:
Faculty of pharmacy, Universiti Kebangsaan
Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
Friday, October 21, 2016
Thursday, October 13, 2016
Sub Cellular Organelles-targeting Photo Dynamic Therapy (PDT)
Article Details
Synthesis Methods for Halogenated Calix[4]Arenes
Author(s):
This review presents synthesis methods for halogenated calix[4]arenes at the
upper rim and in meta-position of phenolic unit as well as at the lower rim by
substitution of hydroxyl group by halogen atom; methods for introducing the
atom of iodine, bromine and chlorine into the molecule of calix[4]arenes; the
advantages and disadvantages of each method.
This review presents synthesis methods for halogenated calix[4]arenes at the upper rim and in meta-position of phenolic unit as well as at the lower rim by substitution of hydroxyl group by halogen atom; methods for introducing the atom of iodine, bromine and chlorine into the molecule of calix[4]arenes; the advantages and disadvantages of each method.
Friday, October 7, 2016
New Issue ::: Mini Review in Organic Chemistry, 13 Issue 5
Mini Review in Organic Chemistry publishes original letters, mini-reviews and guest edited issue in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.
Articles from the journal Letters in Organic Chemistry, 13 Issue 5
- The Substation Effect on Energetic Property and Aromatization of Some Benzamide Derivatives: A DFT Study
- XI. The Use of D Index in the Characterization of Antiaromatic Compounds. The Case of Fullerene
- An Improved Synthesis of the Antimicrobial Thymol- and Carvacrol-β-D-Glucopyranosides
- Synthesis and Chemical Structure Elucidation of Two Schiff Base Ligands, Their Iron(II) and Zinc(II) Complexes, and Antiradical, Antimicrobial, Antioxidant Properties
- A New and Convenient Synthesis of the Boceprevir P1 Fragment, β-amino-α-Hydroxy Amide
- NbCl5 as an Expeditious Catalyst for the Synthesis of Quinoxalinyl and Dibenzodioxepinyl Phosphonates/Phosphinates via Michaelis-Arbuzov Reaction and their Biological Evaluation
- A New Index for the Estimation of the Aromatic Character – X
- Copper Nanoparticle Mediated ‘Click Glycosylation’ for the Synthesis of Fluorinated Triazole Derivatives
- Silica Tethered Ruthenium Catalyst for the Hydrogenation of CO2 Gas
- An Improved Synthetic Route to Rigid Triphenylene Ketal Bearing Structural Bicyclic Subunits
For details on the articles, please visit this link :: http://bit.ly/2bhV8WN
courtesy by https://benthamsciencepublishers.wordpress.com/2016/09/15/new-issue-letters-in-organic-chemistry-13-issue-5/
Friday, September 30, 2016
Organic Chemistry Volume 13 Issue 3
Organic Chemistry publishes original letters, mini-reviews and guest edited issue in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.
The journal is an essential reading for all organic chemists belonging to both academia and industry.
Articles from the journal Letters in Organic Chemistry, Volume 13 Issue 3:
- Synthesis of 1,8-Dioxo-Decahydroacridines using Pyridinium Hydrogen Sulfate Ionic Liquid as an Green, Efficient and Reusable Catalyst
- 4-(1-Adamantyl)phenylalkylamines with Potential Antiproliferative Activity
- Easy Removal of N-carboxybenzyl (Cbz) Protective Group by Low- Carbon Alcohol
- Spectroscopic Properties and Preparation of Some 2,3-Dimethoxybenzamide Derivatives
- Efficient and Selective N-, S- and O-Acetylation in TEAA Ionic Liquid as Green Solvent. Applications in Synthetic Carbohydrate Chemistry
- CaF2 Catalyzed Chemoselective Oxidation of Sulfides to Sulfoxides with Hydrogen Peroxide Under Solvent-Free Conditions
- Microwave-Assisted Synthesis of Novel Bisspiropyrrolidine Thiochromanone Derivatives and Antifungal Activity
- Stereoselective Cyclopropanation Under Solvent Free Conditions: Catalyzed by a Green and Efficient Recyclable Cu-Exchanged Bentonite
- An Efficient Three-Component Reaction of Sodium Azide, Haloalkane and Alkyne for the Synthesis of 1, 2, 3-Triazoles Catalyzed by the Bifunctional Ionic Liquid Catalyst Choline Chloride-CuCl in Water
- New Facile, Eco-Friendly and Rapid Synthesis of Trisubstituted Alkenes Using Bismuth Nitrate as Lewis Acid
For details on the articles, please visit this link :: http://bit.ly/1W7Vxa7
courtesy by https://benthamsciencepublishers.wordpress.com/2016/03/10/new-issue-letters-in-organic-chemistry/
Friday, August 19, 2016
Application Progress of Recent Advances in Some Copper Catalyzed Coupling Reactions
Author(s):
Sunil U. Tekale, Vivekanand B. Jadhav, Vijay P. Pagore, Sushma S. Kauthale, Digambar D. Gaikwad and Rajendra P. PawarPages 281-301 (21)
Abstract:
Different cross-coupling reactions for the formation of biologically important motifs and intermediates in organic synthesis using various suitable copper catalysts are reviewed. These include C-C, C-N, C-O, C-S heteroatom bond forming, cyclization and other miscellaneous reactions catalyzed by elemental copper, copper salts, CuI, Cu (OTf)2, CuBr, Cu2O etc. The use of copper reagents instead of palladium catalysts and ligands seems to be advantageous from the commercial point of view. The methods described herein afford the products in excellent yield without using expensive and moisture/air sensitive palladium catalysts, ligands and reagents.
Keywords:
Copper catalysts, Cross coupling reactions, Ligands.
Affiliation:
Department of Chemistry, Shri Muktanand College, Gangapur - 431 109 (MS) India.
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Morphine as a Potential Oxidative Stress-Causing Agent
Author(s):
Jitka Skrabalova, Zdenka Drastichova and Jiri NovotnyPages 367-372 (6)
Abstract:
Morphine exhibits important pharmacological effects for which it has been used in medical practice for quite a long time. However, it has a high addictive potential and can be abused. Long-term use of this drug can be connected with some pathological consequences including neurotoxicity and neuronal dysfunction, hepatotoxicity, kidney dysfunction, oxidative stress and apoptosis. Therefore, most studies examining the impact of morphine have been aimed at determining the effects induced by chronic morphine exposure in the brain, liver, cardiovascular system and macrophages. It appears that different tissues may respond to morphine diversely and are distinctly susceptible to oxidative stress and subsequent oxidative damage of biomolecules. Importantly, production of reactive oxygen/nitrogen species induced by morphine, which have been observed under different experimental conditions, can contribute to some pathological processes, degenerative diseases and organ dysfunctions occurring in morphine abusers or morphine-treated patients. This review attempts to provide insights into the possible relationship between morphine actions and oxidative stress.
Keywords:
Morphine, oxidative stress, reactive oxygen and nitrogen species.
Affiliation:
Department of Physiology, Faculty of Science, Charles, University, 128 44 Prague 2, Czech Republic.
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Molecularly Imprinted Polymers’ Applications: A Short Review
Author(s):
Paulina Szatkowska, Marcin Koba, Piotr Koslinski and Michal SzablewskiPages 400-408 (9)
Abstract:
Linus Pauling has assumed that certain molecules such as functional monomers make self-organized structures around another particle called a molecular template or stamp. Although this theory has proved to be wrong in terms suggested by Pauling, it became the basis for the synthesis of entirely new materials named molecularly imprinted polymers (MIPs) which entered with great dynamics in the world of science in the early 90s of the last century and gradually gaining more and more popularity. These materials are created by using molecular imprinting techniques, providing selective binding property of the spaces within the polymer molecule of a substance used as a “molecular stamp”. The versatility of the process of synthesizing certain molecules on these materials (which can be drugs, pesticides, carbohydrates, nucleotides, proteins) according to simple modification properties obtained a matrix, by selecting the appropriate functional monomer and process conditions. These fillers provide very selective recognition and differentiation of the enantiomers which are particularly useful in medicinal chemistry. For that reason, they find application in almost every area of life, where the chemical analysis is required. MIPs, due to their compatibility to highly complex matrices, are often used for pharmaceutical and biological estimations. In environmental analysis, MIPs are utilized to detect trace amounts of substances, while used in bromatological and toxicological studies as a useful tool in monitoring norms of dangerous and undesirable chemicals. Hence, the article is a review of the current considerations on the preparation and application of MIPs as well as molecularly imprinted membranes (MIM).
Keywords:
Molecularly imprinted polymer (MIP), Molecularly Imprinted Membrane (MIM), pharmaceutical analysis, toxicological analysis.
Affiliation:
Department of Toxicology, Faculty of Pharmacy, Collegium Medicum of Nicolaus Copernicus University, Bydgoszcz, Poland.
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Cycloaddition Reactions of Some Tricyclic Imides
Author(s):
Irem Kulu, Melek Gul, Omer Tahir Gunkara and Nuket OcalPages 409-418 (10)
Abstract:
Our research group has published numerous papers over the last three years on the reaction of nitrile oxides and azomethine ylide with unsaturated tricyclic N-substituted dicarboximides selected according to the importance of possible biological activities. These reactions cover full range of mechanistic pathways and timings of bond-forming processes to give five-membered ring closure by 1,3-dipolar cycloaddition.
Keywords:
Azomethine ylide, biological active molecules, 1, 3-dipolar cycloaddition, hydrazones, isoxazolines, nitrile oxides, tricyclic imides.
Affiliation:
Yildiz Technical University, Faculty of Science and Arts, Davutpasa Campus, 34220 Istanbul, Turkey.
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M13 Bacteriophage-Based Self-Assembly Structures and Their Functional Capabilities
Author(s):
Jong-Sik Moon, Won-Geun Kim, Chuntae Kim, Geun-Tae Park, Jeong Heo, So Y. Yoo and Jin-Woo OhPages 271-281 (11)
Abstract:
Controlling the assembly of basic structural building blocks in a systematic and orderly fashion is an emerging issue in various areas of science and engineering such as physics, chemistry, material science, biological engineering, and electrical engineering. The self-assembly technique, among many other kinds of ordering techniques, has several unique advantages and the M13 bacteriophage can be utilized as part of this technique. The M13 bacteriophage (Phage) can easily be modified genetically and chemically to demonstrate specific functions. This allows for its use as a template to determine the homogeneous distribution and percolated network structures of inorganic nanostructures under ambient conditions. Inexpensive and environmentally friendly synthesis can be achieved by using the M13 bacteriophage as a novel functional building block. Here, we discuss recent advances in the application of M13 bacteriophage self-assembly structures and the future of this technology.
Keywords:
Biocompatibility, genetic engineering, M-13 bacteriophage, self-assembly.
Affiliation:
Department of Nano Fusion Technology, Pusan National University, Busan 609-735, Republic of Korea; and BIO-IT Foundry Technology Institute, Pusan National University, Busan 609-735.
Graphical Abstract:
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