Wednesday, November 23, 2016
Thursday, November 10, 2016
Call For Paper
Bentham Science Publishers would like to invite you to submit your research paper for publishing in the Journal of
Thursday, November 3, 2016
Highlighted Artcile: Metalloporphyrins in Drug and Pesticide Catalysis as Powerful Tools to Elucidate Biotransformation Mechanisms
Metalloporphyrins in Drug and Pesticide Catalysis as Powerful Tools to Elucidate Biotransformation Mechanisms
Author(s):
Lucas D. Zanatta, Isaltino A. Barbosa, Paulo C. de Sousa Filho, Fabricio B. Zanardi, Lucas B. Bolzon, Osvaldo A. Serra and Yassuko Iamamoto Pages 281 - 288 ( 8 )
Abstract:
Water pollution levels are rising worldwide, so new tools that can over- come the harmful effects of pollutants to the environment and living organisms are welcome. In this context, metalloporphyrins (MePs) mimicking cytochrome P-450 enzymes can contribute to the production of metabolites and help to elucidate bio- transformation processes. MePs can promote chemo-, regio-, and stereoselective transformations under mild conditions, which is highly desirable when investigating the metabolism of drugs or pesticides that currently contaminate natural waters. MeP models can be tailored by introducing electrophilic groups into different posi- tions of the porphyrin ring and by choosing suitable oxygen donors to activate the catalyst and generate the high-valence intermediate species. This mini-review aims to show a recent breakthrough in the use of MePs as a powerful tool to predict which metabolites arise during biotransformation assays. It also aims to highlight the versatility of such models regarding the current challenges in catalytic conversion of xenobiotics.
Keywords:
Biomimetic catalyst, drug, metabolism, metalloporphyrin, oxidation, pesticide.
Affiliation:
Department of Chemistry - Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto - University of Sao Paulo.Ribeirao Preto, SP, Brazil.
Graphical Abstract:
For More Information Please Visit Our Website Mini Review in Organic Chemistry
Thursday, October 27, 2016
Most Accessed Article: Review of Methods and Various Catalysts Used for Chalcone Synthesis
Review of Methods and
Various Catalysts Used for Chalcone Synthesis
Author(s):
Syed Nasir Abbas Bukhari, Malina Jasamai,
Ibrahim Jantan and Waqas Ahmad Pages 73 - 83 ( 11 )
Abstract:
Chalcones are the main precursors for the
biosynthesis of flavonoids and isoflavonoids. Chalcones comprise of a three
carbon α, β-unsaturated carbonyl system. These are the condensation products of
aromatic aldehyde with acetophenones in the presence of catalyst. They go through
a variety of chemical reactions and are found beneficial in synthesis of
pyrazoline, isoxazole and an assortment of heterocyclic compounds. Chalcones
play pivotal role in synthesizing a range of remedial compounds. They have
exhibited impressive curative efficacy for the treatment of numerous diseases.
Chalcone based derivatives have gained focus since they possess simple
structures and sundry pharmacological actions. A number of techniques and
schemes have been reported for the synthesis of these compounds. Amongst all
the stated methods, Aldol condensation and Claisen-Schmidt condensation still
hold high position. Other renowned techniques include Suzuki reaction, Witting
reaction, Friedel-Crafts acylation with cinnamoyl chloride, Photo-Fries
rearrangement of phenyl cinnamates etc. These innovative techniques employ
various catalysts and reagents including SOCl2 natural phosphate, lithium
nitrate, amino grafted zeolites, zinc oxide, water, Na2CO3, PEG400,
silicasulfuric acid, ZrCl4 and ionic liquid etc. The development of improved
strategies for the synthesis of α, β- unsaturated carbonyl compounds is still
in demand. Briefly, we have explained the methods and catalysts used in the
synthesis of chalcones in a review form to provide information for the development
of new-fangled processes aiming better yield, less reaction time and minimum
side effects.
Keywords:
Chalcones, claisen-schmidt condensation,
flavonoids, anticancer, anti- inflammatory
Affiliation:
Faculty of pharmacy, Universiti Kebangsaan
Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
Friday, October 21, 2016
Thursday, October 13, 2016
Sub Cellular Organelles-targeting Photo Dynamic Therapy (PDT)
Article Details
Synthesis Methods for Halogenated Calix[4]Arenes
Author(s):
This review presents synthesis methods for halogenated calix[4]arenes at the
upper rim and in meta-position of phenolic unit as well as at the lower rim by
substitution of hydroxyl group by halogen atom; methods for introducing the
atom of iodine, bromine and chlorine into the molecule of calix[4]arenes; the
advantages and disadvantages of each method.
This review presents synthesis methods for halogenated calix[4]arenes at the upper rim and in meta-position of phenolic unit as well as at the lower rim by substitution of hydroxyl group by halogen atom; methods for introducing the atom of iodine, bromine and chlorine into the molecule of calix[4]arenes; the advantages and disadvantages of each method.
Friday, October 7, 2016
New Issue ::: Mini Review in Organic Chemistry, 13 Issue 5
Mini Review in Organic Chemistry publishes original letters, mini-reviews and guest edited issue in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.
Articles from the journal Letters in Organic Chemistry, 13 Issue 5
- The Substation Effect on Energetic Property and Aromatization of Some Benzamide Derivatives: A DFT Study
- XI. The Use of D Index in the Characterization of Antiaromatic Compounds. The Case of Fullerene
- An Improved Synthesis of the Antimicrobial Thymol- and Carvacrol-β-D-Glucopyranosides
- Synthesis and Chemical Structure Elucidation of Two Schiff Base Ligands, Their Iron(II) and Zinc(II) Complexes, and Antiradical, Antimicrobial, Antioxidant Properties
- A New and Convenient Synthesis of the Boceprevir P1 Fragment, β-amino-α-Hydroxy Amide
- NbCl5 as an Expeditious Catalyst for the Synthesis of Quinoxalinyl and Dibenzodioxepinyl Phosphonates/Phosphinates via Michaelis-Arbuzov Reaction and their Biological Evaluation
- A New Index for the Estimation of the Aromatic Character – X
- Copper Nanoparticle Mediated ‘Click Glycosylation’ for the Synthesis of Fluorinated Triazole Derivatives
- Silica Tethered Ruthenium Catalyst for the Hydrogenation of CO2 Gas
- An Improved Synthetic Route to Rigid Triphenylene Ketal Bearing Structural Bicyclic Subunits
For details on the articles, please visit this link :: http://bit.ly/2bhV8WN
courtesy by https://benthamsciencepublishers.wordpress.com/2016/09/15/new-issue-letters-in-organic-chemistry-13-issue-5/
